The Mid-South Ghana Conference is part of the Southern Ghana Union Conference. It was formerly part of South Ghana Conference and was organized in 2015. It was reorganized and its territory divided in 2017. Mid-South Ghana Conference covers a section of the Central Region of the Republic of Ghana, including Upper Denkyira District in the north; Twifo Hemang Lower Denkyira District in the west; Assin Foso District in the east; and Mfanteman District, Komenda Edina Eguafo District, and Cape Coast Metropolis in the south.